The links between basic and clinical cardiac electrophysiology.
نویسندگان
چکیده
منابع مشابه
The links between basic and clinical cardiac electrophysiology.
FORTY OR 50 years ago, the terms "clinical" and "basic" cardiac electrophysiology described two sides of the same coin. The clinical electrophysiologist was an electrocardiographer; the basic electrophysiologist used electrographic and electrocardiographic techniques to study the hearts of animals or isolated tissues obtained therefrom. Clinical and basic electrophysiol-ogists shared a common l...
متن کاملCardiac electrophysiology of adenosine. Basic and clinical concepts.
A denosine is an endogenous nucleoside that has potent electrophysiologic effects.1-4 As an antiarrhythmic agent, adenosine has several unique properties: 1) it is an intermediate metabolite (Figure 1), 2) it has a very short half-life (less than 1.5 seconds), 3) its effects are mediated by specific membrane receptors coupled to guanine nucleotide binding proteins (G proteins), and 4) it has si...
متن کاملBasic Cardiac Electrophysiology: Excitable Membranes
D.C. Sigg et al. (eds.), Cardiac Electrophysiology Methods and Models, DOI 10.1007/978-1-4419-6658-2_2, © Springer Science + Business Media, LLC 2010 Abstract Cardiomyocytes are excitable cells that have the ability to contract after excitation; therefore, each heartbeat is an event of electrical–mechanical coupling. Cardiac electrical activity at different levels can be measured through variab...
متن کاملThe year in clinical cardiac electrophysiology.
number of studies of genetic and molecular effects on rrhythmogenesis are noteworthy. ong QT syndrome (LQTS). Despite the great advances n our understanding of the role of channel disorders as auses for the LQTS, at present in at least 25% of these atients no genetic defect has been established. The idenified mutant genes are responsible for coding either the lpha (membrane spanning) or rarely ...
متن کاملEResearch Advances Series Cardiac Electrophysiology of Adenosine Basic and Clinical Concepts Bruce
A denosine is an endogenous nucleoside that has potent electrophysiologic effects.1-4 As an antiarrhythmic agent, adenosine has several unique properties: 1) it is an intermediate metabolite (Figure 1), 2) it has a very short half-life (less than 1.5 seconds), 3) its effects are mediated by specific membrane receptors coupled to guanine nucleotide binding proteins (G proteins), and 4) it has si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 1988
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.77.2.251